Biochemical changes in cultured foetal rat liver explants
نویسندگان
چکیده
منابع مشابه
Aluminum-induced neurofilamentous changes in cultured rat dorsal root ganglia explants.
Intrathecal administration of aluminum (AI) salts to susceptible species causes prominent accumulations of neurofilaments (NFs) in neurons of the CNS. Involved nerve cells display abnormal phosphorylation of perikaryal NFs, impaired axonal transport of NFs, and reduced levels of mRNA for NF proteins. Further understanding of the pathogenesis of AI toxicity has been limited by difficulties inher...
متن کاملGlucocorticoids induce the expression of the uteroglobin gene in rabbit foetal lung explants cultured in vitro.
In 27-day-old rabbit foetal lung explants cultured in vitro, the synthesis of the protein uteroglobin decreased progressively during several days of culture. Addition of glucocorticoids to the medium progressively induced the synthesis of uteroglobin in a dose-dependent manner without affecting the synthesis of total proteins. The glucocorticoid-mediated induction of uteroglobin appears mainly ...
متن کاملChanges in levels of argininosuccinate lyase mRNA during induction by glucagon and cyclic AMP in cultured foetal-rat hepatocytes.
During the perinatal period, the activity of the urea-cycle enzyme argininosuccinate lyase (ASL) is regulated by glucocorticoids, glucagon and insulin. In this study, the effects of glucagon and cyclic AMP (cAMP) analogues were examined on the synthesis of ASL and on the level of its corresponding mRNA in cultured foetal hepatocytes. Northern-blot analysis revealed that these agents only gave a...
متن کاملGlutathione and catalase suppress TGFβ-induced cataract-related changes in cultured rat lenses and lens epithelial explants
PURPOSE The damaging effects of oxidative stress and transforming growth factor-beta (TGFbeta)-induced transdifferentiation of lens epithelial cells have both been implicated independently in the etiology of cataract. The aim of this study was to investigate whether the presence of antioxidant systems in the lens influences the ability of lens epithelial cells to respond to TGFbeta. METHODS W...
متن کاملHistopathologic Changes of Rat Liver Following Formaldehyde Exposure
Purpose: This study was designed to determine the histopathologic changes of rat liver while all of the experiments were exposed to formaldehyde for 18 weeks. Materials and Methods: This study was performed on 28, 6-7 week postantal allbino wistar rats. The rats were divided into 3 case groups (E1: 4h/d, 4d/w; E2: 2h/d, 4d/w; E3: 2h/d, 2d/w) and 1 control group. The liver specimens were sectio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1975
ISSN: 0306-3283
DOI: 10.1042/bj1500269